Bacterial Inactivation of the Anticancer Drug Doxorubicin
نویسندگان
چکیده
منابع مشابه
Doxorubicin-Conjugated Immuno-Nanoparticles for Intracellular Anticancer Drug Delivery
A polymeric nanoparticle comprised of surface furan groups is used to bind, by Diels–Alder (DA) coupling chemistry, both targeting anti-human epidermal growth factor receptor 2 (anti-HER2) antibodies and chemotherapeutic doxorubicin (DOX) for targeted, intracellular delivery of DOX. In this new approach for delivery, where both chemotherapeutic and targeting ligand are attached, for the first t...
متن کاملThe distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.
PURPOSE Anticancer drugs gain access to solid tumors via the circulatory system and must penetrate the tissue to kill cancer cells. Here, we study the distribution of doxorubicin in relation to blood vessels and regions of hypoxia in solid tumors of mice. EXPERIMENTAL DESIGN The distribution of doxorubicin was quantified by immunofluorescence in relation to blood vessels (recognized by CD31) ...
متن کاملAssociation of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells
The Werner (WRN) gene codes for a DNA helicase that contributes to genomic stability and has been identified as the gene responsible for progeria. Recent studies have shown reduced WRN expression due to aberrant DNA hypermethylation in cancer cells. Furthermore, WRN expression is thought to affect sensitivity to DNA topoisomerase I inhibitors in c...
متن کاملComparison of Doxorubicin Anticancer Drug Loading on Different Metal Oxide Nanoparticles
Nanomaterials are being vigorously investigated for their use in anticancer drug delivery regimes or as biomarkers agents and are considered to be a candidate to provide a way to combat severe weaknesses of anticancer drug pharmacokinetics, such as their nonspecificity. Because of this weakness, a bigger proportion of the drug-loaded nanomaterials flow toward healthy tissues and result in undes...
متن کاملIron(III)-binding of the anticancer agents doxorubicin and vosaroxin.
The Fe(iii)-binding constant of vosaroxin, an anticancer quinolone derivative, has been determined spectrophotometrically and compared with the analogous Fe(iii) complex formed with doxorubicin. The in vivo metabolic stability and iron coordination properties of the quinolones compared to the anthracylines may provide significant benefit to cardiovascular safety. The mechanism of action of both...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2012
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2012.08.011